William W Seeley Selected Research

Corticobasal Degeneration

1/2020	4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration.
11/2019	C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy.
10/2019	Profound degeneration of wake-promoting neurons in Alzheimer's disease.
1/2019	Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
1/2019	18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes.
12/2017	Clinicopathological correlations in behavioural variant frontotemporal dementia.
10/2017	18 F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study.
1/2016	Atrophy, hypometabolism and clinical trajectories in patients with amyloid-negative Alzheimer's disease.
1/2016	Distinct Lysosomal Network Protein Profiles in Parkinsonian Syndrome Cerebrospinal Fluid.
1/2015	Predicting amyloid status in corticobasal syndrome using modified clinical criteria, magnetic resonance imaging and fluorodeoxyglucose positron emission tomography.

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William W Seeley Research Topics

Disease

49	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 06/2012
39	Frontotemporal Dementia (Semantic Dementia) 01/2022 - 03/2010
33	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 11/2022 - 03/2010
17	Tauopathies 01/2021 - 09/2010
14	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 08/2011
13	Atrophy 01/2022 - 10/2002
12	Dementia (Dementias) 01/2022 - 05/2010
11	Corticobasal Degeneration 01/2020 - 03/2010
9	Primary Progressive Aphasia 01/2019 - 09/2013
8	Cognitive Dysfunction 01/2022 - 09/2011
8	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 07/2020 - 09/2015
6	Disease Progression 01/2022 - 01/2016
5	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2022 - 08/2011
4	Amyloid Plaque 10/2021 - 04/2015
4	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2019 - 01/2013
4	Parkinson Disease (Parkinson's Disease) 10/2017 - 09/2013
4	Sarcoma (Soft Tissue Sarcoma) 09/2013 - 07/2010
3	Proteostasis Deficiencies 01/2022 - 01/2017
3	Chronic Traumatic Encephalopathy 01/2022 - 12/2016
3	TDP-43 Proteinopathies 12/2020 - 06/2015
3	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 12/2019 - 01/2017
3	Neuroinflammatory Diseases 01/2019 - 09/2011
3	Pick Disease of the Brain (Pick's Disease) 01/2018 - 12/2006
2	Muscular Diseases (Myopathy) 01/2022 - 06/2011
2	Osteitis Deformans (Paget's Disease of Bone) 01/2022 - 06/2011
2	Parkinsonian Disorders (Parkinsonism) 01/2022 - 01/2016
2	Autoimmune Diseases (Autoimmune Disease) 12/2016 - 09/2013
1	Movement Disorders (Movement Disorder) 01/2022
1	Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy) 01/2022
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 01/2022
1	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2022
1	Neuromuscular Diseases (Neuromuscular Disease) 01/2022
1	Neoplasms (Cancer) 01/2022
1	Cardiomyopathies (Cardiomyopathy) 01/2022
1	Memory Disorders (Memory Loss) 01/2022
1	Pathologic Processes 12/2021
1	Brain Diseases (Brain Disorder) 01/2020
1	Sporadic Creutzfeldt-Jakob Disease 08/2019
1	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 08/2019
1	Gliosis 08/2019
1	Acquired CJD 08/2019
1	limbic-predominant age-related TDP-43 encephalopathy 01/2019
1	Mixed Dementias 12/2018
1	Aphasia (Dysphasia) 01/2018

Drug/Important Bio-Agent (IBA)

26	Biomarkers (Surrogate Marker)IBA 01/2022 - 10/2002
22	Proteins (Proteins, Gene)FDA Link 01/2022 - 07/2010
22	Amyloid (Amyloid Fibrils)IBA 10/2021 - 03/2013
17	ProgranulinsIBA 01/2021 - 03/2010
15	DNA-Binding Proteins (DNA Binding Protein)IBA 11/2022 - 07/2010
7	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 11/2019 - 10/2013
6	Apolipoproteins E (ApoE)IBA 01/2019 - 06/2012
5	Biological ProductsIBA 01/2021 - 09/2015
5	7- (6- fluoropyridin- 3- yl)- 5H- pyrido(4,3- b)indoleIBA 01/2020 - 02/2017
5	tau Proteins (tau Protein)IBA 11/2019 - 12/2006
5	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 02/2013
4	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2022 - 09/2014
4	PrionsIBA 01/2019 - 06/2014
4	2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA 01/2018 - 03/2013
3	Amyloid beta-PeptidesIBA 01/2022 - 07/2020
3	GranulinsIBA 01/2021 - 06/2015
3	Pharmaceutical PreparationsIBA 06/2014 - 01/2013
2	Valosin Containing ProteinIBA 01/2022 - 06/2011
2	Peptides (Polypeptides)IBA 12/2021 - 10/2021
2	Threonine (L-Threonine)FDA Link 01/2021 - 02/2015
2	Protein AggregatesIBA 01/2020 - 01/2019
2	AntibodiesIBA 10/2019 - 09/2010
2	LipidsIBA 09/2019 - 01/2019
2	LigandsIBA 08/2019 - 01/2019
2	RNA (Ribonucleic Acid)IBA 01/2019 - 08/2011
2	UbiquitinIBA 12/2017 - 07/2010
2	Apolipoprotein E4IBA 01/2017 - 01/2013
2	Complement System Proteins (Complement)IBA 05/2016 - 07/2010
2	Ataxin-2IBA 10/2014 - 08/2011
2	RNA-Binding Protein FUSIBA 01/2012 - 07/2010
1	AutoantibodiesIBA 01/2022
1	TESIBA 01/2022
1	lonafarnib (SCH 66336)IBA 01/2021
1	Peptide Hydrolases (Proteases)FDA Link 01/2021
1	ras ProteinsIBA 01/2021
1	Farnesyltranstransferase (Farnesyltransferase)IBA 01/2021
1	Protein Isoforms (Isoforms)IBA 12/2020
1	FluorineIBA 01/2020
1	Indicators and Reagents (Reagents)IBA 01/2020
1	Glucosylceramidase (Glucocerebrosidase)IBA 12/2019
1	LipofuscinIBA 12/2019
1	SphingolipidsIBA 12/2019
1	EnzymesIBA 12/2019
1	Neurotransmitter Agents (Neurotransmitter)IBA 10/2019
1	Monoamine Oxidase (MAO)IBA 08/2019
1	THK5351IBA 08/2019
1	Autophagy-Related ProteinsIBA 01/2019
1	HLA-DQA2 antigenIBA 01/2019
1	Fibrinogen (Factor I)FDA Link 01/2019
1	Carrier Proteins (Binding Protein)IBA 01/2019
1	ChromatinIBA 01/2019
1	HLA-DRB1 Chains (HLA DRB1)IBA 10/2018
1	Untranslated RNA (Noncoding RNA)IBA 10/2018

Therapy/Procedure

8	Therapeutics 01/2022 - 01/2013
1	Physical Therapy Modalities (Physical Therapy Technique) 01/2022
1	Occupational Therapy (Therapy, Occupational) 01/2022